Effectiveness of single dose treatment with chloroquine of malaria in West Africa and measurement of chloroquine urinary excretion.
نویسندگان
چکیده
A study on the in vivo sensitibity of Plasmodium falciparum to chloroquine was carried out among i to 14 year old schoolchildren in a rural area near Bobo-Dioulasso (Burkina Faso). A single oral dose of chloroquine of 10 mglkg induced a complete disapppearance of all asexual stages from peripheral blood lasting two weeks. Measurement of urinary chloroquine excretion by a colorimetric method did not enable to distinguish the further spontaneous consumers of chloroquine.
منابع مشابه
Malaria drug - resistance in Iran
Introduction: Malaria is a public health problem for approximately 2.4 billion people, 40% of the world’s population, particularly in the tropical and subtropical countries. Countries in Asia, and Latin America, the islands of the South, West, and central pacific ocean are all affected. Drug resistance is the greatest challenge in combating against malaria. Drug resistance in malaria is now w...
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Natural product-derived drugs exemplified by quinine, isolated from South American Cinchona species and artemisinin discovered in China are of immense importance for the treatment of malaria. Although malaria parasites resistant to artemisinin have not yet been found in malaria patients, the need for new antimalarial agents remains. The burden of malaria is heaviest in Africa where over a milli...
متن کاملClinical Pharmacology of the Antimalarial Chloroquine in Children and Their Mothers
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Natural product-derived drugs exemplified by quinine, isolated from South American Cinchona species and artemisinin discovered in China are of immense importance for the treatment of malaria. Although malaria parasites resistant to artemisinin have not yet been found in malaria patients, the need for new antimalarial agents remains. The burden of malaria is heaviest in Africa where over a milli...
متن کاملThe Effect of Otostegia persica in Combination with Chloroquine on Chloroquine-Sensitive and Chloroquine-Resistant Strains of Plasmodium berghei Using In-vivo Fixed Ratios Method
Malaria is one of the worldwide parasitic diseases which threaten the life of hundreds of millions of people at the malarious areas each year. The emergence of chloroquine-resistant strains of Plasmodium falciparum in most of the malarious areas has encountered the relevant countries with some difficulties about treating the acute cases of the disease particulary if the monotherapy regimen h...
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عنوان ژورنال:
- Annales de la Societe belge de medecine tropicale
دوره 67 4 شماره
صفحات -
تاریخ انتشار 1987